Notification of abstract acceptance
announced via E-mail on July 31st.
Abstract view



Oct. 18 (Thu)  Grand Ballroom 105 Room - SS11 NR
16:10-16:20 [SS 11 NR-02] 
Effect of APOE Epsilon 4 Allele on Partial Volume-Corrected Diffusion Anisotropy in Patients with Alzheimer’s Disease and Mild Cognitive Impairment
   
● Speaker Kyung Mi Lee (Graduate School of Medicine, Kyung Hee University)
● Authors Kyung Mi Lee,Eui Jong Kim2,Geon-Ho Jahng3,Woo Suk Choi2,Sun Mi Kim3,Chang Woo Ryu3
● Affiliation Graduate School of Medicine, Kyung Hee University1,Kyung Hee University Medical Hospital2,Kyung Hee University Hospital at GangDong3
● PDF View  SS 11 NR-02.pdf

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PURPOSE:
To prospectively evaluate whether carriers of apolipoprotein E 4 (APOE4) were altered in brain diffusion anisotropy compared with noncarriers in subjects with Alzheimer disease (AD) or mild cognitive impairment (MCI) compared with cognitively normal (CN) subjects

MATERIAL AND METHODS:
25 AD, 25 MCI, and 25 CN subjects underwent isotropic volumetric T1WI and DTI-MRI with being taken blood samples to determine APOE genotypes. Among the subjects, 14 AD, 5 MCI and 5 CN subjects were APOE4 carriers. A brain atrophy correction method was applied on FA and trace maps to test voxel-based comparisons between carriers and noncarriers for each subject groups.

RESULTS:
GM volumes and FA values were significantly reduced and trace values were significantly increased in AD compared to MCI & CN subjects. HypoCBF values were observed in AD compared with MCI & CN subjects. Additionally, CBF values in MCI subjects were increased in left parahippocampal gyrus compared with CN subjects.

CONCLUSION:
Multimodal investigations can demonstrate patterns of concordance or dissociation in imaging results in AD & MCI subject. Concordance areas were mainly in temporal and parietal lobes. APOE4 carrier status is associated with structural changes in white matter integrity in patients with AD. Therefore, multimodal approaches that include regional perfusion imaging are advantageous in the diagnosis of AD and MCI.

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