Notification of abstract acceptance
announced via E-mail on July 31st.
Abstract view
Oct. 18 (Thu) Grand Ballroom 103 Room - SS09 AB
17:50-18:00 [SS 09 AB-12] Assessment of Nonalcoholic Fatty Liver Disease Using Intravoxel Incoherent Motion (IVIM) diffusion-weighted MRI: An Experimental Study in a Rabbit Model Fed with High-Fat, High-Cholesterol Diet
● Speaker
Ijin Joo (Seoul National University Hospital)
● Authors
Ijin Joo,Jeong Min Lee,Joon Koo Han,Byung Ihn Choi
PURPOSE: To evaluate the feasibility of intravoxel incoherent motion (IVIM) diffusion-weighted MRI parameters for the diagnosis of nonalcoholic fatty liver disease (NAFLD) and to determinate optimal cutoff values of IVIM parameters for severity assessment of NAFLD using a rabbit model.
MATERIALS AND METHODS: Twenty-seven male New Zealand White rabbits of 8-week-old were used. After a different feeding schedule -a standard diet for 4 weeks (n=6: control), a standard diet for 3 weeks followed by high-fat, high-cholesterol (HFHC) diet for 1 week (n=6), a HFHC diet for 4 weeks (n=6), and a HFHC diet for 7 weeks (n=9)-, IVIM diffusion-weighted MRI were performed at 3T scanner using multiple b values. IVIM parameters including apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) of the liver parenchyma were measured. Based on histologic features using NAFLD activity score (NAS), each subject was categorized as one of the NAFLD severity groups: normal (NAS=0), not-nonalcoholic steatohepatitis (not-NASH) (NAS=1-2), borderline (NAS=3-4), or NASH (NAS≥5). IVIM parameters were compared among the NAFLD severity groups using Kruskal-Wallis test, and optimal cutoff values of IVIM parameters for severity assessment of NAFLD were determined by a receiver-operating characteristics (ROC) analysis
RESULTS: f values significantly decreased with severity of NAFLD, with median values of 22.2% in normal, 14.8% in not-NASH, 11.3% in borderline, and 9.5% in NASH (P<0.05). ADC, D, and D* did not show significant difference among the NAFLD severity groups. In terms of f values, the area under the ROC curves were 0.984 (normal vs. ≥not-NASH), 0.959 (≤not-NASH vs. ≥borderline), and 0.903 (≤borderline vs. NASH) with optimal cutoff values of 15.2%, 13.2%, and 11.0%, respectively.
CONCLUSION: f values extracted from IVIM MRI would help to differentiate normal liver from NAFLD and to determine the severity of NAFLD.
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SS 09 AB-12.pdf
