Notification of abstract acceptance
announced via E-mail on July 31st.
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Oct. 18 (Thu)  Grand Ballroom 101 Room - SS07 TH
16:40-16:50 [SS 07 TH-05] 
Radiofrequency ablation for autonomously functioning thyroid nodules: Multicenter study of Korean Society of Thyroid Radiology (KSThR)
   
Speaker Jin Yong Sung (Daerim St. Mary's Hospital)
Authors Jin Yong Sung,Jung Hwan Baek2,So Lyung Jung3,Ji Hoon Kim4,Kyu Sun Kim1,Ducky Lee1,Jeong Hyun Lee2,Young Kee Shong2,Dong Kyu Na5
Affiliation Daerim St. Mary's Hospital1,Asan Medical Center2,The Catholic University of Korea, Seoul St. Mary's Hospital3,Seoul National University Hospital4,Human Medical Imaging & Intervention Center5
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PURPOSE:
Some alternative have been introduced to treat autonomously functioning thyroid nodules (AFTN) to overcome several drawbacks of radioactive iodine therapy and surgery. The aim of this study is to evaluate the efficacy and safety of radiofrequency ablation (RFA) to treat AFTN.

MATERIALS AND METHODS:
This study included 44 patients (2 males and 42 females, aged 43±14.7 years) with AFTN who refused or were not suitable for surgery or radioiodine therapy. Twenty three (52.3%) patients were affected by a toxic nodule and 21 (47.7%) by a pre-toxic nodule. RFA was performed using an 18-gauge internally cooled electrode. Nodule volume, thyroid function, scintigraphy, symptom score (0-10), cosmetic score (1-4), and complications were evaluated before treatment and each follow-up.

RESULTS:
Mean follow up period was 16.1±12.5 months. Mean nodule volume was 18.47±30.06mL, initially and significantly decreased at 1-month (11.83±26.91mL, P < .001), 6-months (7.02±14.65mL, P < .001), and the last month (4.71±10.07mL, P < .001). Significant improvement of mean T3, fT4, and TSH was observed at last follow-up (T3, from 179.28±102.54 to 132.76±63.98ng/dL, P < .001; fT4, from 1.94±1.29 to 1.34±0.45ng/dL, P < .001; TSH, from 0.12±0.12 to 1.49±2.18mU/mL, P < .001). Regarding scintigraphy, 34 hot nodules became a cold or normal scan and 10 decreased in size, but remained as hot nodules. The mean symptom and cosmetic scores were significantly reduced at last follow-up from 3.3±2.1 to 0.9±1.0 (P < .001) and from 3.8±0.5 to 1.8±0.9 (P < .001), respectively. No major complications were encountered.

CONCLUSIONS:
RFA significantly reduce nodule volume and, improvement of symptom, cosmetic problems, and thyroid function as well as seems to be safe for treating AFTN.

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