Notification of abstract acceptance
announced via E-mail on July 31st.
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Oct. 18 (Thu)  Grand Ballroom 101 Room - SS01 TH
10:40-10:50 [SS 01 TH-07] 
Proper indication of BRAFV600Emutation testing in fine needle aspirates of thyroid nodules
   
Speaker Jieun Koh (Severance Hospital)
Authors Jieun Koh,Jong Rak Choi1,Kyung Hwa Han1,Eun-Kyung Kim1,Jung Hyun Yoon2,Hee Jung Moon1,Jin Young Kwak1
Affiliation Severance Hospital1,CHA University, CHA Bundang Medical Center2
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PURPOSE:
It is unclear whether if BRAFV600E mutation analysis should routinely accompany ultrasound-guided fine-needle aspiration in the diagnosis of malignancy in patients with thyroid nodules considering its cost-effectiveness. The aim of this study was to evaluate the proper indication of adjunctive BRAFV600E mutation analysis at the time of ultrasound-guided fine-needle aspiration in the diagnosis of thyroid nodules.

MATERIALS AND METHODS:
This study included 518 nodules in 479 patients who underwent ultrasound-guided fine-needle aspiration with BRAFV600E mutation analysis using dual priming oligonucleotide-based multiplex polymerase chain reaction. We calculated and compared the diagnostic performances of cytology and cytology with BRAFV600E mutation analysis to detect malignancy among thyroid nodules according to ultrasound features and size.

RESULTS:
Sensitivity, negative predictive value, and accuracy of cytology with BRAFV600E mutation analysis were significantly higher than those of cytology alone in thyroid nodules with suspicious ultrasound features in nodules regardless of size. Diagnostic performances did not show significant differences between cytology and cytology with BRAFV600E mutation analysis in nodules without any suspicious ultrasound features, regardless of size.

CONCLUSION:
The BRAFV600E mutation analysis was a useful adjunctive diagnostic tool in the diagnosis of thyroid nodules with suspicious ultrasound features regardless of size.

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